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Pharmacology6 min read

Insulin and Glucose Management in Surgical Patients: What CSTs Should Understand

How perioperative blood glucose is managed in surgical patients, including insulin use, and why glucose control matters for surgical outcomes.

February 26, 2026

Why Blood Glucose Control Matters in Surgery

Research has consistently linked poorly controlled perioperative blood glucose, both hyperglycemia and hypoglycemia, to worse surgical outcomes, including elevated surgical site infection rates, impaired wound healing, and longer hospital stays. This connection has made perioperative glucose management a standard, actively monitored part of surgical care rather than an incidental concern only relevant to patients with diagnosed diabetes.

Why Surgery Itself Raises Blood Glucose

The physiologic stress response to surgery triggers the release of stress hormones, including cortisol and catecholamines, which increase blood glucose levels independent of a patient's baseline diabetes status, meaning even non-diabetic patients can experience meaningful hyperglycemia during and after significant surgical procedures. This is part of why blood glucose monitoring has become routine in many surgical protocols, not limited exclusively to patients with a known diabetes diagnosis.

Insulin Types Used in the Perioperative Setting

Rapid-acting insulin, most commonly regular insulin in the acute perioperative setting, is used to correct elevated blood glucose quickly when needed during surgery, administered intravenously by anesthesia based on measured glucose levels rather than on a fixed schedule. Patients on long-acting basal insulin as part of their regular diabetes management typically require specific preoperative instructions about adjusting their usual dose, since insufficient or excessive basal insulin coverage heading into surgery can create either dangerous hyperglycemia or hypoglycemia during the procedure.

Insulin Infusion Protocols in Complex Cases

In longer, higher-acuity procedures, particularly cardiac surgery, some facilities use a continuous intravenous insulin infusion protocol, with frequent glucose checks guiding dose adjustments throughout the case, rather than relying solely on intermittent correction doses. This tighter glucose control approach reflects the particularly strong evidence linking glucose management to outcomes in cardiac surgical populations specifically.

Recognizing Hypoglycemia Risk

While hyperglycemia receives significant attention, hypoglycemia during surgery carries its own serious risks, and because a sedated or anesthetized patient cannot report the typical symptoms of low blood sugar, such as shakiness or confusion, the surgical team must rely entirely on glucose monitoring rather than patient-reported symptoms to catch this complication. Understanding that both directions of glucose imbalance carry real risk helps a surgical technologist appreciate why this monitoring receives consistent attention throughout a case.

  • Both hyperglycemia and hypoglycemia during surgery are linked to worse outcomes
  • The surgical stress response can raise blood glucose even in non-diabetic patients
  • Rapid-acting insulin corrects elevated glucose during a case, while basal insulin adjustment matters preoperatively
  • Sedated patients cannot report hypoglycemia symptoms, making monitoring essential

Point-of-Care Glucose Testing in the OR

Blood glucose monitoring during surgery typically relies on point-of-care testing devices that provide rapid results directly at the bedside rather than requiring samples to be sent to a central laboratory, allowing anesthesia to make timely dosing adjustments based on current readings rather than waiting for delayed lab results. The surgical technologist should understand that these point-of-care checks are happening throughout longer cases, particularly for patients with known diabetes or those receiving corticosteroids, and should recognize this as a routine, ongoing part of case management rather than an unusual occurrence.

Facilities generally follow specific quality control protocols for point-of-care glucose testing devices, ensuring measurement accuracy, and while this quality assurance process is managed by nursing and laboratory staff rather than the surgical technologist directly, understanding that these devices undergo regular calibration checks reinforces confidence in the readings the team relies on throughout a case.

Point-of-Care Glucose Testing in the OR

Blood glucose monitoring during surgery typically relies on point-of-care testing devices that provide rapid results directly at the bedside rather than requiring samples to be sent to a central laboratory, allowing anesthesia to make timely dosing adjustments based on current readings rather than waiting for delayed lab results. The surgical technologist should understand that these point-of-care checks are happening throughout longer cases, particularly for patients with known diabetes or those receiving corticosteroids, and should recognize this as a routine, ongoing part of case management rather than an unusual occurrence.

Facilities generally follow specific quality control protocols for point-of-care glucose testing devices, ensuring measurement accuracy, and while this quality assurance process is managed by nursing and laboratory staff rather than the surgical technologist directly, understanding that these devices undergo regular calibration checks reinforces confidence in the readings the team relies on throughout a case.

This point-of-care testing model, providing rapid results directly where care is happening rather than through a centralized laboratory, reflects a broader trend across perioperative medicine toward faster, more responsive monitoring technology, supporting the kind of real-time clinical decision-making that longer, more complex surgical cases increasingly depend on.

A Physiologic Thread Running Through Many Cases

Glucose management represents a physiologic thread running through many different surgical cases regardless of specialty, since patients with diabetes undergo every type of surgery discussed throughout our content, making this pharmacology knowledge broadly applicable rather than confined to any single specific procedure type.

Recognizing this broad applicability reinforces why building genuine fluency with perioperative glucose management pays dividends across your entire surgical technology career, regardless of which specific specialty you ultimately focus on.

Review related content on high-alert medications in the operating room, and see our surgical pharmacology cheat sheet for more medication content. Create a free account to access structured pharmacology practice questions.

This content is for educational purposes only. SurgicalTechPrep is independently developed and is not affiliated with, endorsed by, or sponsored by NBSTSA, AST, or any official certification body. All clinical information should be verified with current standards of practice.

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